Progentec® Research Technologies

 Progentec has established a strong R&D culture and has successfully undertaken multiple projects and R&D initiatives over time. We are well positioned to offer the following services:

• Research Consulting Services – Progentec is well positioned to provide expert advice and assistance in implementing various research projects.

• Remote Studies – Progentec has carried out multiple remote studies using our patient outreach capabilities combined with digital and remote patient monitoring technologies, virtual care infrastructure and high complexity lab services.

• Our Testing capabilities are listed below.

Please contact us at research@progentec.com with your specific research needs.

Immunoassays

Performance

Progentec has extensive experience performing immunoassays using state of the art microfluidic Simple Plex cartridges run and analyzed on the Ella instrument. This assay system offers many superior performance advantages including:

• Sub-picogram level sensitivity

• 4+ logs of dynamic range

• Reproducibility that meets or exceeds the best laboratory automation

Multiplex Format

The multiplex format of Simple Plex assays on Ella provides a novel, highly robust and flexible approach to multiplexing that utilizes minimal sample to maximize accurate data collection. The spatial separation of each the assay for each analyte into three Glass Nano Reactors (GNRs) eliminates the possibility of any interference or cross reactivity between assays and provides triplicate answers for each sample.

Menu of Analytes for Human, Mouse and Rat. There is an extensive menu of 191 human analytes for Research and Clinical applications to cancer, inflammation, neuroscience, cell therapy, and COVID-19 immune response. A select menu of mouse and rat analytes are also available (Please contact us at research@progentec.com for additional information).

Sample Types

Assays validated and characterized for a broad variety of sample types including:

• Cell Culture Supernatant

• Serum

• Plasma

• Urine

• Saliva

• Cerebrospinal Fluid

Progentec utilizes the Luminex Magpix System for multiplex analysis of protein biomarkers. This quantitative method can analyze up to 50 unique analytes in a single well of a 96-well plate. Numerous manufacturers offer array kits for key pathways in several species including human, primate, mouse, rat, porcine, and bovine. Contact us with the analytes of interest, the species and sample type (serum, plasma, cell supernatants, urine, saliva, tears, etc.) and we will identify the optimal assay systems for your project. You can also use the Luminex® Kit Finder at this link to explore the possibilities. Over 110 protein array kits are available from top manufacturers including R&D Systems, Bio-Rad, Life Technologies, and EMD Millipore. Examples of the panels available include:

• Bone Metabolism

• Cancer Biomarkers

• Cardiovascular

• Cell Signaling

• Endocrinology

• Immunology/Immune Response

• Metabolism

• Neuroscience

• Toxicology

If your research requires analysis of proteins not available in any of these manufactured kits, we also have experience with development of custom arrays. Like the manufactured kits custom arrays have the potential to analyze up to 50 unique analytes in a single well of a 96-well plate. The cost of a custom array project is dependent on the number and complexity of the specific targets related to analyte compatibility and potential cross reactivity. Please contact our development team to have your custom array project evaluated.

Progentec employs the BioMark HD which is a high throughput capacity automated real-time PCR system based on microfluidics technology. The system is sample-sparing with capabilities of processing samples at nanoliter-level volumes in integrated fluidic circuit formats making it ideal for analyzing hundreds to thousands of samples per chip (9216 samples/chip on a 96 x 96 format). Available applications include: 

• TaqMan Gene Expression

• Single Cell Gene Expression

• TaqMan Genotyping

• Copy Number Variation

• Sample Identification

Available panels for specific applications include:

• SNP Genotyping Pharmacogenomics Panels

• Therapeutic Drug Metabolism

• Pain Management/Opiod

• Psychotropic Metabolism

• Custom TaqMan Genotyping

• CYP2D6 Copy Number Variation

• Custom Copy Number Variation

• RNA Expression Panels

• Autoimmune

• Gastrointestinal Pathogen

• Wound Care/Wound Healing

• Custom TaqMan Gene Expression

Please contact us with your assay requirements and we will determine the optimal standard or custom design for accomplishing your goals. The cost of a custom project is dependent on the number of required targets and their uniqueness and complexity. Please contact our development team to have your custom SNP genotyping or RNA expression project evaluated.